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Days after learning he had cancer, high school basketball star dies a day before graduation – Washington Post

Posted: June 23, 2017 at 8:40 pm

Redondo High basketball standout Ryse Williams came down with what he thought was a cold about a month ago. He didnt think much of it at the time and continued to hit the gym daily, training for what was supposed to be his freshman season at Loyola Marymount this fall. But the 18-year-olds illness didnt go away; it only got worse and in the past two weeks and he landed in the hospital, where, Redondo basketball Coach Victor Martin told the Daily Breeze(Torrance, Calif.), Williams first learned his cold was actually a rare form of cancer that had spread to his lungs and liver.

On Thursday, just a day before he was set to graduate, Williams died. By the time medical staff atChildrens Hospital Los Angeles attempted to treat Williamswith chemotherapy, his cancer, the type of which has not been released,had already progressed to stage IV. No treatment could save him.

Were all sad and shocked, Athletic Director Andy Saltsman told the newspaper.

Hes unbelievably tough to have this cancer in his body all this time, Martin added.

Its unclear when Williams learned he had cancer. In a text message exchange from June 12 that one of his former high school classmates shared on Twitter on Thursday, Williams wrote he had some infection or virus that had spread through my lungs kidney and liver.

When University of Kansas commit Billy Preston asked him if he was all right, Williams remained optimistic: Im getting better fam, he said, although noting hed been in the ICU since he was admitted to the hospital on June 8.

That Williams remained optimistic likely doesnt come as a surprise to his friends, family or coaches.

[Hes] Just a great young man, Saltsman told the Daily Breeze. He obviously was a great basketball player, and he was a true leader for the team, but he was an even better person.

In a short essay he posted to Twitter, Redondo junior point guard Caleb Christopher said he looked toward Williams as a brother.

At times, basketball didnt matter, we were just having fun enjoying life, he said. Ryse was the first to show me the true meaning of style, fashion and creating your own wave. And watch how others follow. And if you had Ryse you had a friend no matter what. He hung out with everybody. Always dancing and smiling.

Williams earned the respect of both his teammates and opponents on and off the court. Named 2017 Bay League Most Valuable Player, the 6-foot-2, 185-pound senior averaged 20 points and five rebounds a game, leading Redondo to its fifth straight Bay League title and a spot in the Southern Section Open Division playoffs, where the team would eventually bounce out in the second round, according to USA Today.

Outside of high school, Williams played for the Cal Supreme AAU program on the Nike EYBL circuit, where he faced off against the likes of Shaquille ONeals son Shareef, who was one of many to express his shock and condolences at Williamss unexpected death.

Redondo principalJens Brandt informed the school on Thursday of Williamss death, sending a letter to the students and their families, noting the school planned to do something special to remember Williams during Fridays graduation ceremony.

Students at Redondo didnt wait to show their respects, however, as they set up a memorial outside of Redondos school gymnasium and later held a candlelight vigil.

Officials from Loyola Marymount, where Williams verbally committed to last July and signed his letter of intent in November, also reacted to Williamss death.

I send my heartfelt sympathy on behalf of our program and my staff to the family of Ryse, Lions Coach Mike Dunlap said in a statement. As good of a basketball player as he was, it was his personality and character that stood above all.

You never want to hear of a young person who is unable to fully make his mark on the world, Loyola Marymount Athletic Director William Husak added. On behalf of the Athletics Department and Loyola Marymount University, we send our condolences and support to the Williams family and the mens basketball community.

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Days after learning he had cancer, high school basketball star dies a day before graduation – Washington Post

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EU regulators greenlight US biotech Aveo’s kidney cancer drug – Reuters

Posted: at 8:40 pm

European regulators on Friday recommended the approval of Aveo Pharmaceuticals Inc’s drug to treat kidney cancer, marking a big victory for the U.S. biotech that has faced a number of setbacks in bringing the drug to the market.

Aveo’s shares surged 58 percent to $1.15 in premarket trading.

The European Medicines Agency (EMA) said experts at its Committee for Medicinal Products for Human Use (CHMP) had backed the oral, once-daily drug for marketing approval as a first-line treatment for advanced renal cell carcinoma, or kidney cancer.

The drug was also backed for treating adult patients with advanced kidney cancer who met certain criteria and had received one prior treatment with cytokine therapy, the EMA said.

Recommendations for marketing approval by the CHMP are normally endorsed by the European Commission within a couple of months.

Europe has among the highest incidence rates of kidney cancer in the world, with about 115,000 people diagnosed with cancers of the kidney, renal pelvis and the ureter in 2012.

The green light from the EMA comes after a series of stumbles for Aveo’s drug, tivozanib, or Fotivda.

The treatment, first licensed by Aveo from Japan’s Kyowa Hakko Kirin over seven years ago, was turned down by the U.S. Food and Drug Administration (FDA) in 2013 for inconsistent study results.

The company has since ended an agreement with Astellas Pharma Inc to help develop the drug.

Aveo paid $4 million last year to settle allegations that it misled investors about U.S. regulators’ concerns over its drug.

To seek FDA approval for Fotivda as a first- and third-line treatment for kidney cancer, Aveo will test the drug in a trial pitting the treatment against Bayer and Amgen’s approved drug for kidney cancer, Nexavar, or sorafenib.

Results from the trial are expected in the first quarter of 2018.

Aveo granted specialty pharmaceutical business EUSA Pharma the European rights to tivozanib for the treatment of kidney cancer.

(Reporting by Esha Vaish in Bengaluru; Editing by Sai Sachin Ravikumar)

NEW YORK Health insurers are concerned about the U.S. Senate’s plans to cut the Medicaid program for the poor and the impact such a move would have on state governments, the industry’s largest lobbyist said on Friday.

ZURICH A European Medicines Agency (EMA) panel recommended on Friday approving Novartis’s Kisqali drug, bolstering the Swiss drugmaker’s bid to challenge rival Pfizer’s Ibrance against tough-to-treat breast cancer.

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EU regulators greenlight US biotech Aveo’s kidney cancer drug – Reuters

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FDA padlocks any new human tests on Seattle Genetics’ cancer drug in the wake of more deaths – Endpoints News

Posted: June 22, 2017 at 10:46 am

Clay Siegall, CEO, Seattle Genetics

In the wake of Seattle Genetics announcement that a disturbing tilt in deaths pointed to a likely safety problem for its late-stage cancer drug vadastuximab talirine (SGN-CD33A), the FDA has stepped in to yank the IND and officially put any human testing on hold.

The biotech $SGEN reported the FDAs move in a filing with the SEC this morning.

Seattle Genetics had already hit the brakes on its R&D work on the drug three days ago, scrapping the Phase III for acute myeloid leukemia and ordering a halt to any other testing until they can get a better read on the situation. It will also have to convince regulators that the drug is safe for testing after the FDA had lifted its first clinical hold on the drug just three months ago. That first hold on its early-stage work came after four patients died.

Those deaths were linked to liver toxicity, a classic red flag on safety. But this time one of the few clues provided by Seattle Genetics is that liver toxicity did not appear to be behind the disturbing rate of deaths investigators were seeing.

Back in March the biotech reported that it was getting restarted on the clinical work after it came up with revised eligibility criteria and stopping rules for veno-occlusive disease.The FDA agreed to lift the hold only two months after it was dropped on Seattle Genetics.

With its big Immunomedics deal axed by activists and its lead clinical drug in big trouble, Seattle Genetics CEO Clay Siegall will come under heavier pressure to diversify beyond Adcetris.

News reports for those who discover, develop, and market drugs. Join 16,000+ biopharma pros who read Endpoints News articles by email every day. Free subscription.

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BRCA1, BRCA2 study provides new clarity on breast cancer risk for carriers of gene mutations – ABC Online

Posted: at 10:46 am

Updated June 21, 2017 08:32:00

A new study has provided a better understanding of the risk of breast cancer for carriers of the BRCA1 and BRCA2 gene mutation, which points to the need for early identification and lifelong monitoring of the disease.

The study published in the Journal of the American Medical Association involved almost 10,000 women in Australia, the United States and Europe over 20 years and was done by Peter MacCallum Cancer Centre, the University of Melbourne and Cancer Council Victoria researchers.

The study found that those with the BRCA1 mutation had, on average, a 72 per cent risk of developing breast cancer by the age of 80.

The risk of developing ovarian cancer for those women was on average 44 per cent.

For those with the BRCA2 mutation, the risk of breast cancer was 69 per cent and the lifetime risk of ovarian cancer was 17 per cent.

There is a 4 per cent margin of error in those figures, researchers said.

Professor John Hopper, the National Health and Medical Research Council senior principal research fellow from the University of Melbourne, was co-lead author of the report.

What made the findings so significant, he said, was that rather than being based on retrospective data, looking back at groups of women with the same risk factors, these findings were based on more accurate information called prospective data.

“We have followed women forward in time. So we’ve been back to them every few years and given them questionnaires,” Professor Hopper said.

“We start the clock when the women come along and we follow them forward, so we get a proper idea of what their risks are.

“Now we’ve got incredible precision.”

Professor Hopper said they already knew the risks were high for women in this group, possibly as high as 90 per cent, but they were not as high as originally thought.

“We’ve now stabilised what we think the average risk is, but we’ve learnt a lot more,” he said.

“One of the things we’ve learnt is that the risk also depends on a woman’s family history and it also depends on where the mutation was on the gene.

“So not every mutation has the same risk.”

But along with the findings come new concerns.

Researchers have found out that once a woman’s risk becomes elevated, it remains high for the rest of her life.

That risk peaks in the 30s for women with the BRCA1 mutation and in the 40s for carriers of BRCA2.

Professor Hopper said they now had a much better insight to advise women about what their risks were and what their options were, depending on their age, family history and the characterisations of the mutation itself.

“In terms of prevention, we really need to be looking at a young age, especially for mutation carriers,” he said.

“Understanding the genetics of breast cancer and other things is making us realise that we have to think about breast cancer control at a much younger age than just when women start to get increased risk in their 50s and 60s.

“If you think you might be a mutation carrier, it’s important to know at a young age, if you’re going to think about how to try and control your risk during your lifetime.”

The researchers said eventually they hoped to show that breast and ovarian cancer were not solely caused by a woman’s genes or her environment, but by a combination of both.

Professor Hopper paid tribute to the women who participated in the study.

“The heroes are the women who’ve been in the study that have allowed us to get this information that’s going to be so valuable for future generations,” he said.

Topics: breast-cancer, diseases-and-disorders, health, ovarian-cancer, research, medical-research, melbourne-3000, vic, australia

First posted June 21, 2017 06:33:24

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Minnesota Fraternal Order of the Eagles and RiverView Health Foundation – $5K donation will boost ovarian cancer … – Crookston Daily Times

Posted: at 10:45 am

The Fraternal Order of Eagles held their 114th Minnesota State Convention this past weekend in St. Cloud and at their awards banquet on Thursday night awarded Riverview Health in Crookston a $5,000 grant for ovarian cancer initiatives.

The Fraternal Order of Eagles held their 114th Minnesota State Convention this past weekend in St. Cloud and at their awards banquet on Thursday night awarded Riverview Health in Crookston a $5,000 grant for ovarian cancer initiatives.

Minnesota State Eagles Aerie President Gaylen Dvorsak of Alexandria picked ovarian cancer as his charity and worked with Randy Beggs of Crookston, who has been working at raising funds for this cause since losing his wife Ellen to ovarian cancer in 2016.

One woman dies every 10 hours from ovarian cancer. It could be your mother, wife, sister, friend or even your daughter, said Riverview Health Foundation Director Kent Brunn. If patients are diagnosed and treated in the early stages, the chances of survival increase significantly, which is our motivation behind this grant.

The sobering reality with ovarian cancer is, no screening test exists yet today to diagnose ovarian cancer. This creates a major challenge and it requires that an unconditional commitment by women and the medical professionals to invest in providing increased knowledge and continued education on the symptoms and diagnostics for patients that are or need to be concerned about ovarian cancer.

The exciting news is that statistics show if ovarian cancer is detected at its earliest stage, the five-year survival rate is more than 90 percent. I believe with research we will find a way to diagnose ovarian cancer at an earlier stage, but until that occurs we need to be proactive, Bruun said. It is our responsibility to do this on behalf of the patients we serve.

RiverView Health will continue to grow and sustain a comprehensive ovarian cancer educational program that will effectively raise the awareness to help patients identify their level of risk and better understanding of which health symptoms they need to be watch for, and family histories they need to be aware of.

I applaud the Fraternal Order of the Eagles stakeholders role and commitment to this grant request. I believe in and continue to witness the Eagles commitment to People Helping People, Bruun said. This grant reflects the Eagles organizations positive influence to assist and improve the lives of others. We could not do this ovarian cancer awareness program without their involvement and financial support.

In other Minnesota Eagles State Convention news, three Crookston Eagle members were elected/appointed to serve on the Minnesota State Aerie Executive board. Bruce Meyer was elected as State Aerie Treasure, Randy Beggs was elected State Aerie Conductor, and Jake Fee was appointed as Aerie Assistant State Secretary.

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Minnesota Fraternal Order of the Eagles and RiverView Health Foundation – $5K donation will boost ovarian cancer … – Crookston Daily Times

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Undiagnosed breast cancer in Georgia: despair plays a part – MyAJC

Posted: at 10:45 am

A pair of new studies on breast cancer from Georgia State University point to a surprising medical villain: economic despair.

Both of the GSU studies looked at breast cancer that goes undiagnosed for too long. One of the studies by the universitys School of Public Health, on a type of the disease called Inflammatory Breast Cancer, found a cluster of cases in Southern Georgia that are unlikely to be a coincidence.

The cluster, earlier reported in Georgia Health News, was one of just four such clusters that the study found in the U.S.

That study didnt release the exact locations of the patients for privacy reasons, but it acknowledged that theres a significant African-American population in Georgia, and African-American women tend to be diagnosed with the aggressive, late-stage cancer at much higher rates than whites. Poverty is part of the issue. A higher percentage of African-Americans are lower income than U.S. whites. That can make it harder to have a choice of doctors, or even find time between shifts to get to the doctor.

Poverty status may be the most crucial risk factor, that study found, as it affects many additional factors, such as access to care, screening, transportation, living conditions and housing quality, and employment, which can in turn affect rates of rare BC (breast cancer) diagnosis, that study found.

The second study took a deep dive into the geography of late-stage breast cancer diagnoses generally, and a quirk popped up. One of the risk factors, it turned out, was for white women generally higher-income white women who live in racially segregated rural areas.

Those women had higher rates of late-stage diagnoses breast cancer that had gone undiagnosed for too long than other white women in more diverse areas.

In contrast, some risk factors for African-American women were well known, including less education and information, and economic despair that breeds a reluctance to seek exams for fear of asking for trouble.

The best possible answer the authors came up with, based on other general research, was a growing sense of pessimism among whites that theyve lost ground. That might breed despair and a sense of failurea fatalistic attitude, the authors said, that prompts them to spend less energy getting cancer screenings and keeping good health.

But the authors stressed that there may be other explanations, and more research needs to be done.

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Undiagnosed breast cancer in Georgia: despair plays a part – MyAJC

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Breast cancer survivors can safely have a baby – LaSalle News Tribune

Posted: at 10:45 am

CHICAGO A study gives reassuring news for breast cancer survivors who want to have children. Those who later became pregnant were no more likely to have their cancer come back than those who did not have a baby.

Its a big issue the average age of moms has been rising in the United States, and more women are being diagnosed with breast cancer in their childbearing years. About 11 percent of new breast cancer cases in the U.S. are in women under 45.

The study, done in Europe, is the largest so far on women whose cancers were fueled by hormones, which rise in pregnancy and theoretically, might spur a recurrence.

Having a family is one of the most important achievements in a persons life, said study leader Dr. Matteo Lambertini of the Jules Bordet Institute in Brussels, Belgium. These results show that pregnancy after breast cancer can be considered safe.

The research involved more than 1,200 breast cancer survivors. More than half had tumors whose growth was fueled by estrogen. After treatment, 333 became pregnant, about two and a half years after their cancer diagnosis, on average. Researchers compared them to 874 other survivors, matched for tumor type and other things, who did not.

More than 12 years after conception, recurrence rates were similar in both groups. Abortion had no impact on the rates either.

There was information on breast-feeding for only 64 of the moms, but 25 reported doing so successfully, suggesting its possible for some women even after breast surgery.

The results show fairly convincingly that women dont have to worry, said Dr. Richard Schilsky, chief medical officer for the American Society of Clinical Oncology. The group featured the study at its annual conference earlier this month in Chicago.

A big study underway now in the U.S. and other countries is taking this research one step further, testing whether its safe for breast cancer survivors who want to get pregnant to temporarily suspend taking the hormone-blocking drugs like tamoxifen usually recommended for five years after initial treatment.

If they wait until all five years are past, they might be too old to have a baby, said Dr. Ann Partridge, who specializes in treating young women with breast cancer at Dana-Farber Cancer Institute in Boston. She is helping enroll patients in the study, called POSITIVE.

Participants must have used the hormone blockers for at least 18 months before stopping, and can suspend treatment for up to two years to enable pregnancy, delivery and breast-feeding.

Sarah Murray of Bridgeport, Connecticut, is the first U.S. woman in the study to have had a baby. She was only 29 and planning her wedding when her breast cancer was found in 2013.

We had just set the date when I got diagnosed, the same week. So obviously, children was on our minds, she said.

Worries about triggering a recurrence if she got pregnant did weigh on me quite a bit, she said, but I didnt want the fear to have power over a decision that would bring so much joy.

Her son, Owen, was born in December.

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It’s a G Thing: Northwell Health nurse creates comfort baskets for breast cancer patients – New York’s PIX11 / WPIX-TV

Posted: at 10:45 am

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GREAT NECK, New York- Creativity breeds comfort for Debi Cavolo.We take a basket and we put a little bit of fluff in it,” Debi Cavolo showed us. Every single one is a work of art and a show of support for women battling breast cancer.I want to let them know that theyre not alone so the next patient doesnt feel like I did,” she said.Debi, whos a longtime surgical nurse at North Shore University Hospital, underwent a lumpectomy in 2006 and a bilateral mastectomy in 2012.I just remember feeling so isolated,” she described. “I felt like nobody would understand what I was going through.

While working through her own recovery, she got to work on another project.I knew I wanted to give back and my business partner,Andy Rampersad, [a co-worker] understood my dream,” Cavolo said.So they launched the Breast Cancer Comfort Foundation and began making small gift baskets from her home. Inside are items like a pillbox, journal, tote bag, hot/cold packs, thank you cards, chapstick and much more. “I thought of the things that I would want if I was laying in the bed,” Cavolo explained.

Since 2014, theyve grown from delivering ten baskets a month to more than 50. Doctors saw the immediate impact and they wanted to get involved.A lot of these women are emotional and vulnerable, theyve just had their breasts removed and bringing them this basic brings them comfort knowing someone is thinking of them,” Dr. Neil Tanna described. Dr.Neil Tanna is a plastic surgeon and says a positive attitude means everything to a patients healing.

Im very excited about my little pill thing! Monique smiled.Monique, a school teacher, has battled stage three breast cancer for more than year.My first chemo was January 12 and the same day my grandmother passed away,” she said tearfully. “I realized I need support so anything that can give me a support, Im happy to take.” So getting this pint-sized pink present one day after surgery was more than anything she couldve expected.You feel hope, that shes [Debi] better and got through it so you can too,” she said.

As for Debi, these moments make the long hours and hard work worth it. She says she couldnt do it without her loyal team but credits her brother for inspiring every single day.I keep this around my neck so that I would always have him near me,” Cavolo said holding her necklace.Walter was a New York City firefighter and spent nearly a year helping at ground zero. He was one of the first to lose his life from 9/11-related illnesses.He gave his life and thats why I do this,” she said. “It makes me feel that what I do, how I live makes a difference.”

Produced by: Kim Pestalozzi

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It’s a G Thing: Northwell Health nurse creates comfort baskets for breast cancer patients – New York’s PIX11 / WPIX-TV

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Study: South Georgia ‘hot spot’ for inflammatory breast cancer … –

Posted: at 10:45 am

ATLANTA Inflammatory breast cancer is usually diagnosed at a later stage than other breast cancers and thus is often fatal.

A new Georgia State University study has found that one of the areas with high incidence of inflammatory breast cancer is in south Georgia.

The data are from 2004 to 2012, and the researchers plan to see if those cluster spots remain the same in more recent cases of the cancer.

Researchers looked at more than 20,000 cases of inflammatory breast cancer in 40 states. They found that south Georgia, Dallas and communities in North Carolina appear to contain the bulk of the hot spots.

Inflammatory breast cancer often doesnt appear on a mammogram, says Lee Rivers Mobley, one of the Georgia State researchers.

Often [patients] go to several doctors before being diagnosed properly, Mobley said.

There is no definitively established cause of inflammatory breast cancer, which represents about 3 percent of all breast cancers.

Being in a poor rural area is associated with the cancer, as is being African-American, Mobley said. But IBC is not exclusive to one ethnic group or region.

The Georgia State analysis confirms that IBC rates differ geographically and may be influenced by social, economic and environmental factors, with air, water or soil contamination possible factors, the studys authors say.

Researchers can identify the specific counties where incidence is high but have agreed not to publish them due to concerns about patient privacy. So the map accompanying the research shows vague red spots in the states.

The data with counties identified are available to public health officials, Mobley said.

Dr. Mylin Torres, a breast cancer physician and director of Winships Glenn Family Breast Center at Emory, noted the studys identification of several areas in Georgia with high rates of inflammatory breast cancer.

Torres, who did not have any involvement with the GSU study, pointed out there are many health disparities in Georgia regarding breast cancer. She cited an additional study published last year that found Atlanta, more than any other major U.S. city, has higher rates of breast cancer deaths among black women compared with white women.

Among black women in Atlanta, 44 per 100,000 died of breast cancer in the period 2010 to 2014. Meanwhile, 20 white women per 100,000 died of breast cancer in Atlanta.

Atlanta also had the largest increase in the black/white disparity on breast cancer mortality.

Torres said inflammatory breast cancer is one of the most aggressive, deadly forms of breast cancer. It can spread pretty quickly. The breast cancer gets often mistaken with infection of the breast. Often, theres not a distinct mass within the breast.

Torres said she participated in a small study that found that there was no difference in outcomes between black and white women who received appropriate treatment for IBC.

The lead author of the Georgia State study is Lia Scott, who is working on a PhD in epidemiology at the GSU School of Public Health. The co-authors are Mobley, associate professor of health management and policy, and Dora Ilyasova, associate professor of epidemiology and biostatistics.

While IBC may be unpreventable, a goal is to determine risk factors that may aid in the early detection of the disease, improving survival, the study said.

Torres said the key is early diagnosis and proper treatment, which have been linked to improvements in survival. Future research should be devoted to determining risk factors that may aid in identifying women at risk for IBC, she said.

Results of the GSU study are published in the International Journal of Environmental Research and Public Health.

Andy Miller is editor and CEO of Georgia Health News.

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Advanced breast cancer – Story | WeAreCenralPA | WTAJ – WTAJ

Posted: at 10:45 am

Two-hundred, fifty-three thousand women will be diagnosed this year with invasive breast cancer, and for women battling advanced forms of the disease, theres now a new treatment. Doctors are calling it a first line of defense for advanced breast cancer.

With a hot pink ride, decked out with lighted wheels, nothing is going to get in the way of mother Sally McGiffin and her daughter Shannon McGiffin. Not even cancer.

When we first got diagnosis we sat and cried maybe half an hour to an hour, and then she looked at me and said this disease is not going to beat me, Sally said.

That attitude and a newly-approved FDA drug called Ribociclib, has kept Shannon’s stage four metastic breast cancer under control.

Its a miracle. It really is a miracle for me to be able to have survived this long. Shannon said.

Oncologist Heather Han, MD, of the Moffitt Cancer Center in Tampa, Florida says when combined with hormonal therapy, Ribociclib stops signals that cancer cells use to grow and divide.

Im obviously very excited that this drug finally actually quickly got approved, and Im able to be there to help patients to do better, Dr. Han explained.

Doctor Han says the Ribociclib combination can be used as the first line of defense. The risk of progression or death has been reduced by 44 percent.

Dr. Han continued, So its been in clinical trial for several years, but FDA was able to approve it quickly when it showed dramatic improvement of the patients.

The side effects for her have been high blood sugar levels and fatigue.

I do spend a lot of my time sleeping, Shannon admitted.

For Shannon, its not a cure, but it has given her precious time with those who matter most.

Candidates for this drug usually can be patients with newly diagnosed advanced breast cancer, hormone receptor positive and HER2 negative. Patients EKGs must be monitored in the first few weeks of taking the drug to make sure it doesnt cause any cardiac issues.

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